Cells are commonly surrounded by a nanodimensioned layer of glycoconjugates, called the “glycocalyx”. The question of how Glycocalyx Biochemistry functions in detail is of major interest in the realm of Biological Chemistry. In particular, comparisons of the Glycocalyx Biochemistry of cells that exhibit different states of health and disease may pave the way for hitherto unconsidered methods of treatment. The supramolecular (bio)chemistry of the glycocalyx goes beyond monovalent receptor-ligand interactions. Thus, unraveling the secrets of carbohydrate recognition on the cell surface opens the door to new concepts in Medicinal Chemistry. This video provides an overview of our work on the investigation of carbohydrate-specific bacterial adhesion. We utilize functional glycomimetics and specific glycoarrays that may be fabricated from photoswitchable glycosides.
Thisbe Lindhorst is a Professor for Organic and Biological Chemistry at the Christian-Albrechts-University of Kiel, Germany. Her research interests center on biochemical key issues of the glycosciences. She is also the mother of two children and strongly encourages her students to pursue both an excellent carrier in science and a fulfilling family life.
Katharina Kolbe is a biochemist and doctoral student in the Lindhorst Group. She is interested in the biochemistry of carbohydrate-specific microbial adhesion. Claudia Fessele is a biochemist and doctoral student in the Lindhorst Group. She employs atomic force microscopy and glycosylated nanomaterials to manipulate bacterial adhesion.
Original research articles are published in the Open Access Beilstein Journal of Organic Chemistry and are parts of the Thematic Series Synthesis in the glycosciences and Synthesis in the glycosciences II.
Lindhorst, T. K., Synthesis in the glycosciences, Beilstein J. Org. Chem. 2010, 6, No. 16. doi:10.3762/bjoc.6.16
Lindhorst, T. K., Synthesis in the glycosciences II, Beilstein J. Org. Chem. 2012, 8, 411–412. doi:10.3762/bjoc.8.45