An introduction to immunoglobulin G

Published on June 3, 2013

This video describes the immunoglobulin G antibody and its role in the immune response.

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The structure of the antibody and the importance of its associated carbohydrates are described in detail. Binding of immunoglobulin G to membrane-bound receptors on the surface of immune cells such as B cells, macrophages and natural killer cells leads to initiation or inhibition of an immune response. This process is critical to protect us against infection and cancer through biological processes such as antibody-dependent cellular cytoxicity. Also discussed is how the biopharmaceutical industry is now exploiting antibodies and their properties to provide new treatment options for various diseases. These therapeutic monoclonal antibodies exploit the body’s own immune system in so-called immunotherapy.

Rudd Group and Davey Group | NIBRT and Trinity College, Dublin, Ireland

Professor Pauline M. Rudd heads the Glycobiology Laboratory Research Group at the National Institute for Bioprocessing Research and Training, Dublin, Ireland. Before moving her group to University College Dublin in 2006, Professor Rudd was a University Reader in the Glycobiology Institute at Oxford University. Professor Rudd obtained a BSc in Chemistry at the University of London and a PhD in Glycobiology at the Open University, UK. She was a Founding Scientist of Wessex Biochemicals (later Sigma London). She has been a Visiting Research Associate at The Scripps Research Institute, CA, Visiting Professor of Biochemistry at Shanghai Medical University PRC, Visiting Scientist at Ben Gurion University of the Negev, Israel, and Erskine Visiting Fellow, Canterbury University, Christchurch, New Zealand. She is a Fellow of the Royal Society of Medicine, London and a Visiting Professor at St. George’s Hospital, London. She is an adjunct professor at North Eastern University, Boston, NUI Galway, University College Dublin and Trinity College Dublin.
Dr. Jerrard Hayes is a postdoctoral fellow in Prof. Rudd’s research group at the National Institute for Bioprocessing Research and Training, Dublin. He joined the glycobiology group in 2012 from Trinity college, Dublin. His research interests include immunoglobulin G and Fcγ receptors, a particular type of membrane-bound receptor.
Dr. Gavin Davey is head of Biochemistry and Immunology in Trinity College, Dublin. His research interests include neurodegeneration, stem cells and computer modeling of glycosylation pathways.

Sources

The original research articles are published in the book series Methods in Molecular Biology and the journal Arthritis and Rheumatism.

Royle, L.; Radcliffe, C. M.; Dwek, R. A.; Rudd, P. M. Detailed structural analysis of N-glycans released from glycoproteins in SDS-PAGE gel bands using HPLC combined with exoglycosidase array digestions. In Glycobiology Protocols; Brockhausen, I., Ed.; Methods in Molecular Biology, Vol. 347; Springer Verlag: Berlin, Germany, 2006, pp 125–143. doi:10.1385/1-59745-167-3:125

Ercan, A.; Cui, J.; Chatterton, D. E.; Deane, K. D.; Hazen, M. M.; Brintnell, W.; O’Donnell, C. I.; Derber, L. A.; Weinblatt, M. E.; Shadick, N. A.; Bell, D. A.; Cairns, E.; Solomon, D. H.; Holers, V. M.; Rudd, P. M.; Lee, D. M. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2011, 62, 2239–2248. doi:10.1002/art.27533

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