Conducting Appel reactions in flow using a triphenylphosphine monolith

Published on December 23, 2011

The preparation of a triphenylphosphine monolithic reagent and its application to the Appel reaction in a flow-chemistry setup is explained. The active monolith generates brominated products from the corresponding alcohols in excellent yields and high purity with no requirement for further off-line purification.

Ley Group | University of Cambridge, UK

Professor Steven Ley has been the BP (1702) Professor of Chemistry at the University of Cambridge since 1992. Steve’s research interests are varied and span many disciplines including new synthetic methodologies, the total synthesis of natural products and the development of enabling technologies for chemical synthesis. He has published over 720 papers and has gained 43 major awards including the Tetrahedron Prize for Creativity in Organic Chemistry (Elsevier); the Heinrich Wieland Prize (Boehringer Ingelheim, Germany); the Paracelsus Prize (Swiss Chemical Society) and most recently the Royal Medal (The Royal Society, London).

Kimberley Roper received an MSci in Natural Sciences from the University of Cambridge in 2008 and is currently a final year Ph.D. student in Professor Ley’s research group working towards the application of new technologies within organic synthesis.

Sources

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Chemistry in flow systems II.

Roper, K. A.; Lange, H.; Polyzos, A.; Berry, M. B.; Baxendale, I. R.; Ley, S. V., The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors, Beilstein J. Org. Chem. 2011, 7, 1648–1655. doi:10.3762/bjoc.7.194

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Chemistry in flow systems II.

Roper, K. A.; Lange, H.; Polyzos, A.; Berry, M. B.; Baxendale, I. R.; Ley, S. V., The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors, Beilstein J. Org. Chem. 2011, 7, 1648–1655. doi:10.3762/bjoc.7.194

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