Data Deposition Increases Credibility

Published on November 2, 2017

Discussion with Barbara M. Bakker (University Medical Center Groningen), Carsten Kettner,  Thomas S. Leyh (Albert Einstein College of Medicine), Johann M. Rohwer (University of Stellenbosch) and Reinhard Sterner (University of Regensburg)

recorded at BEILSTEIN ENZYMOLOGY SYMPOSIUM – Enzymes in Transformation and Signalling
Rüdesheim, Germany, 19 – 21 September 2017

At the end of the Beilstein Enzymology Symposium, Carsten Kettner discusses with Barbara Bakker, Thomas Leyh, Johann Rohwer and Reinhard Sterner about the pitfalls when reusing enzyme function data from the literature and databases.

Listen to the views on the following themes:

  • Which information is required to reproduce experiments and reuse experimental data in simulation and modelling?
  • What are the reasons for missing information in papers and what is the role of the journals with regards to quality control?
  • Are reporting guidelines and software tools beneficial for the science community?
  • How burdensome is data input in STRENDA DB considered in comparison to other data acquisition systems?

The panel, each an expert from a different area in enzymology, gave some interesting insights into their experiences with published experimental data and provided a number of ideas on how to increase reproducibility, comparability and reliability of these data.

Please have a look at our other videos with some speakers and their standpoints on Open Science:

Functional Analysis of Promiscuous Enzymes
Karen N. Allen, Boston University, USA

Directed Evolution of Enzymes
Donald Hilvert, ETH Zurich, Switzerland

Efficiency of Enzyme Catalysis
Kenneth A. Johnson, University of Texas at Austin, USA

Nature is the Master of Design
Roland Wohlgemuth, ESAB, Buchs, Switzerland

The Beilstein Enzymology Symposia embrace structural, computational and biological disciplines, and bring researchers (established and younger workers) together to discuss the many and diverse roles of enzymes in biology, and to explore the limits and challenges of holistic studies that attempt to integrate microscopic views of protein function into complex biological behaviour.

This symposium addresses enzymes and other signal‑cascade proteins which capture and transduce these diverse signals into discrete chemical entities that inform and direct cellular behaviour. Molecular-information processing networks require the coordinated interplay of numerous components, and are the focus of systems-biological investigations aimed at understanding, for example, the spread of disease, or identifying targets that can control signal-transduction.

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