Laser rapid prototyping of bioactive materials for medical treatment

Published on June 26, 2014

This video demonstrates an easy and fast method for rapid prototyping of medical treatment devices.

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Burn wounds are very painful and take a very long time to heal. Conventional treatment of burns implies exchange of wound coverages several times per day. By pulsed laser ablation of a metal plate in a water-based monomer solution and simultaneous polymerization, nanoparticles are permanently embedded in a polymer matrix, called microgel. Using electrospinning, these microgels can be easily processed to microfibers for the application as ion-release systems. The release of different bioactive metal ions initiated by the nanoparticles, supports all healing stages and therefore improving the healing process.

The presented project is interdisciplinary lead by Prof. Stephan Barcikowski (Chair of Technical Chemistry I at the University of Duisburg-Essen, Vice-Director of the Center for Nanointegration Duisburg-Essen (CENIDE) and Co-founder of the Particular GmbH), Prof. Andrij Pich (Chair of Functional and Interactive Polymers in the DWI-Leibnitz-Institute for Interactive Materials at the RWTH Aachen), Prof. Peter M. Vogt and Prof. Kerstin Reimers (Chair of Plastic, Hand and Reconstructive Surgery at the Hannover Medical School).

The principal investigators acknowledge the Deutsche Forschungsgemeinschaft (DFG) for generous founding of the Schwerpunktprogramm 1327.

Barcikowski Group | University of Duisburg-Essen, Germany

Nina Million is a Ph.D. student in Technical Chemistry at the University of Duisburg-Essen. For the research on nanoparticle-microgel composites for burn wound treatment, she got the award of the Deutsche Gesellschaft für Biomaterialien (DGBM) for the best master thesis 2013.

Philipp Nachev-Wilke is a Ph.D. student in the DWI – Leibniz-Institute for Interactive Materialials at the RWTH Aachen.

Vincent Coger is a Ph.D. student in the Department of Plastics, Hand and Reconstructive Surgery at the Hannover Medical School.

Sources

van ‘t Zand, D.D. ; Nachev, P. ; Rosenfeld, R., Wagener, P., Pich, A. ; Klee, D. Barcikowski, S.: Nanocomposite Fibre Fabrication via in situ Monomer Grafting
and Bonding on Laser-generated Nanoparticles. JLMN-Journal of Laser Micro/Nanoengineering 2012 Vol. 7 No. 1 via researchgate.net

Publications of the Barcikowski-Group

Scientific videos on the laser prototyping method

Center for Nanointegration Duisburg-Essen

DWI at RWTH Aachen

Hannover Medical School

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