Medicinal inorganic chemistry

Published on July 29, 2014

This video shows the synthesis and applications of new metal compounds for biomedical applications. We use elements all across the periodic table according to the required properties, for example iron, ruthenium, rhenium or gold.

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Metal ions play a vital role in biology. They are cofactors in many enzymes, and they even form part of the active center in as much as one third of all enzymes in the human body. Furthermore, metal compounds have an important role for the human well-being. A few metal complexes even serve as drugs, for example against cancer and bacterial infections. However, this field of metal-based drugs is notably less developed compared to purely organic drugs. Our group explores the synthesis and applications of new metal compounds for biomedical applications. We use elements all across the periodic table according to the required properties, for example iron, ruthenium, rhenium or gold. A particular focus of our work is to exploit the unique properties provided by the metal atoms, such as redox activity or optical properties; and to develop highly cell and tissue-specific, targeted metal bioconjugates. The group runs a full research program including not only synthesis but also physical characterization and investigation of their biological properties. This video gives an overview of the various aspects of our work and an outlook to international cooperations in the field of medicinal inorganic chemistry.

Metzler-Nolte Group | Ruhr University Bochum, Germany

Nils Metzler-Nolte is Professor of Inorganic Chemistry at Ruhr University Bochum since 2006. His work centers around biomedical applications of transition metal compounds and metal-based drugs. Prof. Metzler-Nolte has received several awards for his work on biological inorganic chemistry, and he was speaker of the DFG-funded Research Unit “Bioorganometallic Chemistry”. He is Associate Editor for Dalton Transactions and member of the Interntional Advisory Boards of several other journals. He has organized several national and international meetings, and is currently Council Member of the Society of Biological Inorganic Chemistry, as well as designated Chair of the Gordon Research Conference Metals in Medicine 2016. Prof. Metzler-Nolte was speaker of the University-wide RUB Research School (funded from the German Excellence Initiative), and served his University as Vice President for Early Career Researchers and International Affairs from 2010 – 2012.

Kathrin Klein is a PhD student in the Metzler-Nolte group, she works on novel Ru-based drug candidates.

Daniel Siegmund is a PhD student in the Metzler-Nolte group and develops new Re-based complexes for biomedical imaging purposes.

Marcus Maschke investigates the electrochemical properties of metallocene derivatives as a PhD student in the Metzler-Nolte group, with the aim to understand their anti-proliferative activity.

Martin Strack works as a PhD stundent in the Metzler-Nolte group, the aim of his work is to develop highly cancer-specific Au-based drugs through conjugation to peptides.

www.chemie.rub.de/ac1

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