Nanomechanical sensors for medical applications

Published on July 12, 2012

Based on standard atomic force microscope cantilevers, the group of Prof. Gerber has developed microfabricated nanomechanical cantilever sensor arrays.

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Such sensors represent a powerful platform for a broad range of detection applications in physics, chemistry, material science, biology and medicine. For example, the sensor may respond with mechanical bending due to the absorption of molecules. Here we demonstrate the whole process, beginning with the cantilever functionalization with biomolecules or polymer layers, and ending with the actual measurements. We also highlight some of the applications in biochemistry and medicine. More recent developments comprise membrane surface stress sensors for breath characterization of cancer patients and an outlook to a commercial cantilever sensor instrument.

Gerber Group | University of Basel, Switzerland

Prof. Dr. Christoph Gerber is a founding member and the Director for Scientific Communication of the National Center of Competence in Research “Nanoscale Science” at the Department of Physics, University of Basel, Switzerland. He is a pioneer in scanning probe methods and has made major contributions to the development of the scanning tunneling microscope and the atomic force microscope. He has published more than 160 peer-reviewed papers, resulting in more than 23,000 citations. His IP portfolio contains 37 patents and patent publications.

Dr. François Huber is a biochemist. Primarily, he works on the application of nanomechanical devices for nanomedicine.

Dr. Hans Peter Lang is an experimental solid-state physicist working as a senior scientist in Prof. Gerber’s group. His research focuses on the development of nanomechanical sensors for measurements in gaseous environments.

Dr. Jiayun Zhang is a physicochemist. Her major interest is the development of customer-oriented DNA and protein assays using nanomechanical cantilever biosensors.d Interfaces.

Sources

The original research article is published in the Open Access Beilstein Journal of Nanotechnology.

Backmann, N.; Kappeler, N.; Braun, T.; Huber, F.; Lang, H.-P.; Gerber, C.; Lim, R. Y. H., Sensing surface PEGylation with microcantilevers, Beilstein J. Nanotechnol. 2010, 1, 3–13. doi:10.3762/bjnano.1.2

The original research article is published in the Open Access Beilstein Journal of Nanotechnology.

Backmann, N.; Kappeler, N.; Braun, T.; Huber, F.; Lang, H.-P.; Gerber, C.; Lim, R. Y. H., Sensing surface PEGylation with microcantilevers, Beilstein J. Nanotechnol. 2010, 1, 3–13. doi:10.3762/bjnano.1.2

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