In this video the detailed synthesis of a boron based bidentate Lewis acid is shown step by step. The Lewis acid is used to great success as a catalyst for inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2-diazines with various dienophiles to access substituted aromatic compounds.
Bidentate Lewis Acid Catalysis for Organic Synthesis
Wegner Group | Justus Liebig University Giessen, Germany
Hermann Wegner studied chemistry in Göttingen, Boston, Stanford and Oxford. After completion of his habilitation at the University of Basel he moved to his current position as a Professor for Organic Chemistry at the Justus Liebig University Giessen. His research interests are in Lewis acid catalysis, molecular switches and novel aromatics for functional materials.
Sebastian Ahles joined the group of Prof. Dr. Hermann A. Wegner in 2013. His research interests are in the field of catalyzed IEDDA reactions, synthesis and analysis of carbon rich molecules.
Kessler, S. N., Wegner, H. A.: “Lewis Acid Catalyzed Inverse Electron-Demand Diels-Alder Reaction of 1,2-Diazines” Org. Lett. 2010, 12 (18),4062-4065, DOI: 10.1021/ol101701z.
Kessler, S. N., Neuburger, M. Wegner, H. A.: “Bidentate Lewis Acids for the Activation of 1,2-Diazines – A New Mode of Catalysis.” Eur. J. Org. Chem. 2011, 17,3238–3245, DOI: 10.1002/ejoc.201100335.
To download this video, right-click on the icon. Then, choose “Save … As…” from the menu that appears. Choose a location on your computer to download the file, and then click the “Save” button. All videos published by the Beilstein-Institut on this Web Site are licensed for use in accordance with the Creative Commons License.