Sugar hydrogels as biosensors

Published on June 21, 2013

The video presents a collaboration project between the MPI of Colloids and Interfaces (MPIKGF) and Universität Leipzig on the synthesis of a new class of sugar presenting scaffolds and a novel label free screening method to determine biomolecular interactions.

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Carbohydrates are not merely a source of our nutrition. Many sugars are bioactive in that their structure contains molecular information that is recognized by cell receptors to control various important biological functions, such as cell signaling and immune response. Therefore, the synthesis of complex sugars containing the “right” information and understanding their biomolecular interactions is crucial to the advances in biomedicine and related areas.

Hartmann Group and Schmidt Group | MPI of Colloids and Interfaces Golm and University of Leipzig, Germany

Dr. Laura Hartmann is currently working as an independent Emmy Noether research groupleader at the MPI of Colloids and Interfaces in the Department of Biomolecular Systems. Her research interests focus on the synthesis of biomimetic macromolecules and hydrogels combining synthetic scaffolds based on monodisperse, sequence-defined oligo/polymers with biological ligands such as sugars or peptides. Previously she worked as a postdoc at Stanford University after obtaining her Ph.D. from the University of Potsdam and the MPI of Colloids and Interfaces in the group of H.Börner/M.Antonietti working on polymeric non-viral vectors for gene delivery.

Dr. Stephan Schmidt currently works as an independent researcher at the University of Leipzig in the group of Prof. Tilo Pompe. He received his PhD at the University of Bayreuth under the supervision of Professor Andreas Fery. Since the completion of his PhD he worked as a postdoctoral researcher at the Max-Planck Institute of Colloids and Interfaces before he moved to Leipzig. His research interests are centered on the mechanics and interaction forces of biologically active as well as bioinspired materials. He is particularly interested in the underlying molecular design features and how they control biological functions such as cell adhesion or self healing.

Sinaida Lel is currently working as a Ph.D. student in the group of Dr. Laura Hartmann. Her research interests focus on the synthesis of glycooligo/polymers using solid phase synthesis and studying their biological activity.

Felix Wojcik is currently working as a Ph.D. student in the group of Dr. Laura Hartmann. His research interests focus on the synthesis of glycooligo/polymers using solid phase synthesis and thiol-ene chemistry in flow.

Daniel Pussak is currently working as a Ph.D. student in the groups of Dr. Laura Hartmann and Dr. Stephan Schmidt. His research interests focus on the synthesis of soft colloidal probes and their use as biosensors.

Sources

Original research article:

Daniel Pussak, D.; Ponader, D.; Mosca, S.; Vargas Ruiz, S.: Hartmann, L.; Schmidt. S.;, Mechanical Carbohydrate Sensors Based on Soft Hydrogel Particles, Angewandte Chemie International Edition 2013, 52-23, 6084–6087. doi.org/10.1002/anie.201300469

Wojcik, F.; Lel, S.; O’Brien, A.G.; Seeberger, P.H.; Hartmann, L.; Beilstein J. Org. Chem. 2013, 9, 2395–2403. doi:10.3762/bjoc.9.276

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