Surface patterning for biological applications

Published on January 28, 2014

Our groups deals with different methods for chemical surface patterning with a strong emphasis on biological applications. In this video we show you two methods, micro arraying by microchannel cantilever and Dip-Pen Nanolithography with lipids (L-DPN) as an example of techniques used in our group. One of the applications of these surface patterns is the study of immune cell activation by model allergens. Employing surface patterns in this research gives biologists valuable advantages in regard to experimental control and response read-out.

Research Unit Fuchs | Institute of Nanotechnology, Karlsruhe, Germany

Michael Hirtz is principal investigator for the Dip-Pen Nanolithography (DPN) group of the research unit of Prof. Harald Fuchs. He is exploring the advancement and application of DPN and related techniques for bioactive surface patterning and functionalization of sensor and photonic structures.

Ainhoa Urtizberea is a Marie Curie Fellow in our group studying the details on transfer mechanism and membrane formation during Dip-Pen Nanolithography with lipids (L-DPN).

Sylwia Sekula-Neuner studies the activation of immune cells by allergens and the modulation of immune response of these cells by glucocorticoids on Dip-Pen Nanolithography generated surface patterns.

Sources

The original research article is published in the Open Access Beilstein Journal of Nanotechnology and is part of the Thematic Series “Advances in nanomaterials”.

Hirtz, M.; Lyon, M.; Feng, W.; Holmes, A.E.; Fuchs, H.; Levkin, P.A., Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens, Beilstein J. Nanotechnol. 2013, 4, 377–384. 10.3762/bjnano.4.44

Hirtz, M.; Oikonomou, A.; Georgiou, T.; Fuchs,H.; Vijayaraghavan, A., Multiplexed biomimetic lipid membranes on graphene by dip-pen nanolithography, Nat. Commun. 2013, 4, 2591. 10.1038/ncomms3591

Sekula-Neuner, S.; Maier, J.; Oppong, E.; Cato, A. C. B.; Hirtz, M.; Fuchs, H., Allergen Arrays for Antibody Screening and Immune Cell Activation Profiling Generated by Parallel Lipid Dip-Pen Nanolithography, Small 2012, 8, 585–591. 10.1002/smll.201101694

The original research article is published in the Open Access Beilstein Journal of Nanotechnology and is part of the Thematic Series “Advances in nanomaterials”.

Hirtz, M.; Lyon, M.; Feng, W.; Holmes, A.E.; Fuchs, H.; Levkin, P.A., Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens, Beilstein J. Nanotechnol. 2013, 4, 377–384. 10.3762/bjnano.4.44

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