Synthesis of DNA with optical functionalities

Published on May 8, 2013

In this video, the DNA building block chemistry is described with respect to the modification of DNA by chromophores. Photoswitches as chromophores allow photoinduced color changes in DNA. Combination of two different chromophores enable DNA (i) to display strand displacement by fluorescence color changes, e.g. from green to red and vice versa, and (ii) to act as light harvesting systems.

Wagenknecht Group | Karlsruhe Institute of Technology (KIT), Germany

Hans-Achim Wagenknecht, born in 1968, finished his studies of chemistry at the University of Freiburg with a diploma thesis about glycosidase inhibitors (Prof. Jochen Lehmann). After completion of his Ph.D. in the group of Prof. Wolf-D. Woggon (Basel) about synthetic porphyrin models of chloroperoxidase, he carried out postdoctoral research at the California Institute of Technology (Pasadena) in the group of Prof. Jacqueline K. Barton. In 2000, he started to set up an independent research group at the Technical University of Munich in the field of bioorganic and biophysical chemistry with DNA in order to obtain the habilitation in 2003. In 2005, he moved as a professor for organic chemistry to the University of Regensburg and in 2010 on a chair position at the Karlsruhe Institute of Technology (KIT). His current interest is to develop functional DNA architectures for electron transfer, photocatalysis, fluorescent cellular imaging and nanomaterials.

Sebastian Barrois is a scientific coworker of Professor Wagenknecht since 2011 and deals with photoswitch-modified DNA and several applications of “DNA Traffic Lights” within his dissertation.

Philipp Ensslen is Ph.D. Student in the Wagenknecht Group since 2012, and his research is focused on DNA-based light harvesting systems..

Sources

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Molecular switches and cages.

Diarylethene-Modified Nucleotides for Switching Optical Properties in DNA, Barrois, S; Wagenknecht, H.-A., Beilstein J. Org. Chem., 2012, 8, 905-914, doi:10.3762/bjoc.8.103

S. Barrois, H.-A. Wagenknecht, Org. Biomol. Chem., 2013,11, 3085-3088, doi:10-1039/C3OB40435H

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Molecular switches and cages.

Diarylethene-Modified Nucleotides for Switching Optical Properties in DNA, Barrois, S; Wagenknecht, H.-A., Beilstein J. Org. Chem., 2012, 8, 905-914, doi:10.3762/bjoc.8.103

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