Asymmetric organocatalysis in a ball mill

Published on August 20, 2013

In this video the authors present asymmetric organocatalyses performed in a ball mill. Three reaction types are being discussed: enantioselective aldol reactions, asymmetric Michael additions to nitro alkenes and dipeptide formations. In the laboratory the ball milling device is shown, and reaction details are revealed. Finally, future applications of mechanochemical biomass degradations are highlighted.

Bolm Group | RWTH Aachen University, Germany

Professor Dr. Carsten Bolm is a professor for Organic Chemistry at the RWTH Aachen University, Germany, and adjunct professor at WIT (Wuhan Institute of Technology), China. His research focuses on catalytic organic reactions, synthetic organic chemistry, and biomass utilization.

Professor Dr. Eusebio Juaristi is a professor for Organic Chemistry at Center of Research and Advanced Study of the National Polytechnic Institute in Mexico City. His research focuses on asymmetric organocatalysis and solvent-free organic reactions.

Mr. Manuel Jörres is a doctoral student in the research group of Professor Carsten Bolm at RWTH Aachen University, Germany. His research relates to asymmetric organocatalysis (also performed under uncommon reaction conditions).


Kleine, T.; Buendia, J.; Bolm, C.: Mechanochemical degradation of lignin and wood by solvent-free grinding in a reactive medium, Green Chem. 2013, 15, 612-616. doi: 10.1039/C2GC36456E

Jörres, M.; Mersmann, S.; Raabe, G.; Bolm, C.: Organocatalytic solvent-free hydrogen bonding-mediated asymmetric Michael additions under ball milling conditions, Green Chem. 2013, 15, 160-166. doi: 10.1039/C2GC36906K

Hernández, J. G.; Juaristi, E.: Green Synthesis of r,β- and β,β-Dipeptides under Solvent-Free Conditions, J. Org. Chem. 2010, 75, 7107–7111. doi: 10.1021/jo101159a

Hernández, J. G.; Juaristi, E.: Asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides: improved stereoinduction under solvent-free conditions., J. Org. Chem. 2011, 76, 1464–1467. doi: 10.1021/jo1022469

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