Continuous flow α-aminoxylation monitored by in-situ IR spectroscopy

Published on May 25, 2012

This video demonstrates the advantages of conducting enantioselective α-aminoxylation reactions under continuous-flow conditions. Monitoring of the reaction by in-situ IR spectroscopy allows for the simplified optimization of reaction conditions and flow rate. The use of a polystyrene-immobilized proline-based catalyst facilitates the easy preparation of α-oxy-substituted aldehydes with excellent optical purity and a simplified workup procedure.

Pericàs Group | ICIQ, Tarragona, Spain

Miquel A. Pericàs is a professor at the Institute of Chemical Research of Catalonia (ICIQ) in Tarragona, Spain. He leads a research group working on the design and synthesis of immobilized ligands and catalysts for batch and continuous flow enantioselective processes. He has published more than 230 research papers and 25 patent applications.

Xacobe C. Cambeiro graduated from the University of Santiago de Compostela, Spain and obtained his PhD at the University of Barcelona, Spain under the supervision of Professor Miquel A. Pericàs. Currently he is a postdoctoral research associate in the group of Dr. Igor Larrosa at Queen Mary, University of London, UK.

Andrea Henseler graduated from the University of Cologne, Germany and is currently a PhD student in the Pericàs group working with solid-supported amino-acid-derived catalysts.

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Chemistry in flow systems II.

Cambeiro, X. C.; Martín-Rapún, R.; Miranda, P. O.; Sayalero, S.; Alza, E.; Llanes, P.; Pericàs, M. A., Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline, Beilstein J. Org. Chem. 2011, 7, 1486–1493. doi:10.3762/bjoc.7.172

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