Fluorination in flow

Published on January 9, 2012

The use of the highly reactive gas, elemental fluorine, in continuous flow processes is demonstrated for the synthesis of 4-fluoropyrazole derivatives by a single gas – liquid / liquid – liquid continuous flow process. The procedure involves fluorination of a diketone followed by immediate cyclisation of the fluorodiketone intermediate upon reaction with hydrazine.

Sandford Group | Durham University, UK

Professor Graham Sandford leads the Durham Organofluorine Chemistry Research Group at Durham University, UK. He has published around 130 research papers, review articles and patent applications, mainly in the field of organofluorine chemistry.

Ms. Jessica Breen, a Postgraduate student at Durham University, has recently submitted her PhD thesis on Selective Fluorination strategies.

Sources

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Chemistry in flow systems II.

Breen, J. R.; Sandford, G.; Yufit, D. S.; Howard, J. A. K.; Fray, J.; Patel, B., Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination, Beilstein J. Org. Chem. 2011, 7, 1048–1054. doi:10.3762/bjoc.7.120

The original research article is published in the Open Access Beilstein Journal of Organic Chemistry and is part of the Thematic Series Chemistry in flow systems II.

Breen, J. R.; Sandford, G.; Yufit, D. S.; Howard, J. A. K.; Fray, J.; Patel, B., Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination, Beilstein J. Org. Chem. 2011, 7, 1048–1054. doi:10.3762/bjoc.7.120

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