Nature is the Master of Design

Published on November 2, 2017

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Interview with Roland Wohlgemuth, European Section of Applied Biocatalysis – ESAB, Buchs, Switzerland

recorded at BEILSTEIN ENZYMOLOGY SYMPOSIUM – Enzymes in Transformation and Signalling
Rüdesheim, Germany, 19 – 21 September 2017

Roland Wohlgemuth discusses with Carsten Kettner the need for the interconnection of applied and non-applied catalysis, the first taking place in industrial processes, and the latter is performed in basic research, mainly in academia. Roland emphasizes that there is a need of communication between both parties since many issues arising during industrial processes need to be resolved by addressing fundamental kinetic and mechanistic discoveries. In addition, along with the optimization of known enzymes, both screening of unknown activities and the directed evolution of enzymes can result in the adaption of enzyme activities to reaction conditions used in industrial processes. Good example for a practical problem is the need for enzymes being effective at low temperatures.

Please have a look at our other videos with some speakers and their standpoints on enzyme research:

Functional Analysis of Promiscuous Enzymes
Karen N. Allen, Boston University, USA

Directed Evolution of Enzymes
Donald Hilvert, ETH Zurich, Switzerland

Efficiency of Enzyme Catalysis
Kenneth A. Johnson, University of Texas at Austin, USA

Discussion: Data Deposition Increases Credibility
Barbara M. Bakker, Carsten Kettner, Thomas S. Leyh, Johann M. Rohwer, Reinhard Sterner

The Beilstein Enzymology Symposia embrace structural, computational and biological disciplines, and bring researchers (established and younger workers) together to discuss the many and diverse roles of enzymes in biology, and to explore the limits and challenges of holistic studies that attempt to integrate microscopic views of protein function into complex biological behaviour.

This symposium addresses enzymes and other signal‑cascade proteins which capture and transduce these diverse signals into discrete chemical entities that inform and direct cellular behaviour. Molecular-information processing networks require the coordinated interplay of numerous components, and are the focus of systems-biological investigations aimed at understanding, for example, the spread of disease, or identifying targets that can control signal-transduction.

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