Photoswitchable protein kinase Inhibitors for novel anti-cancer applications

Published on March 16, 2015

The goal of this project is the development and biological characterization of photoswitchable kinase inhibitors which will be useful for innovative therapeutic approaches with focus on anti-cancer applications.

Peifer Group | Christian Albrechts-University of Kiel, Germany

Christian Peifer earned his PhD in medicinal chemistry from the University of Mainz and was postdoc at the University of Tübingen and at the MRC in Dundee, Scotland. He worked as project manager for the company Schrödinger (Molecular Modeling Software) and was appointed as professor at the University of Kiel in 2010. Peifer´s research interest is focusing on a medicinal chemistry platform consisting of design, organic synthesis, and biological evaluation to develop cell permeable small molecule protein kinase inhibitors for neurodegenerative and cancer therapy, cancer diagnosis and signal transduction analysis.

Rebecca Horbert studied pharmacy at the university of Halle and is currently working on her PhD thesis in the group of Prof. Peifer at the university of Kiel. Her research project involves photoactivatable prodrugs of kinase inhibitors for anticancer therapy.

Dorian Schmidt is studying chemistry at the University of Kiel. During his master studies he focused on medicinal chemistry and spent four month at the Ferrier Research Institute in New Zealand.

Boris Pinchuk has studied biochemistry in Kiel. In his PhD thesis he is responsible for the biological evaluation of photo-prodrugs and further kinase inhibitors in our group.


Horbert, R., Pinchuk, B., Johannes, E., Schlosser, J., Schmidt, D., Cappel, D., Totzke, F., Schächtele, F., Peifer, C.: Optimization of Potent DFG-in Inhibitors of Plateled Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics. J. Med. Chem. 2014 Special Issue: New Frontiers in Kinases. DOI: 10.1021/jm500373x.

Pinchuk, B., Johannes, E., Gul, S., Schlosser, J., Schaechtele, C., Totzke, F., Peifer, C.: Marine derived Hamacanthins as lead for the development of novel PDGFRβ protein kinase inhibitors. Marine Drugs 2013, 11, 3209-3223; DOI: 10.3390/md11093209.

Horbert, R.; Pinchuk, B.; Davies, P.; Alessi, D.; Peifer, C.: Photoactivatable prodrugs of anti-melanoma agent vemurafenib. submitted

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