Recipe for the preparation of a bidentate Lewis acid catalyst

Published on June 15, 2015

In this video the detailed synthesis of a boron based bidentate Lewis acid is shown step by step. The Lewis acid is used to great success as a catalyst for inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2-diazines with various dienophiles to access substituted aromatic compounds.

Related Video:
Bidentate Lewis Acid Catalysis for Organic Synthesis

Wegner Group | Justus Liebig University Giessen, Germany

Hermann Wegner studied chemistry in Göttingen, Boston, Stanford and Oxford. After completion of his habilitation at the University of Basel he moved to his current position as a Professor for Organic Chemistry at the Justus Liebig University Giessen. His research interests are in Lewis acid catalysis, molecular switches and novel aromatics for functional materials.

Sebastian Ahles joined the group of Prof. Dr. Hermann A. Wegner in 2013. His research interests are in the field of catalyzed IEDDA reactions, synthesis and analysis of carbon rich molecules.


Kessler, S. N., Wegner, H. A.: “Lewis Acid Catalyzed Inverse Electron-Demand Diels-Alder Reaction of 1,2-Diazines” Org. Lett. 2010, 12 (18),4062-4065, DOI: 10.1021/ol101701z.

Kessler, S. N., Neuburger, M. Wegner, H. A.: “Bidentate Lewis Acids for the Activation of 1,2-Diazines – A New Mode of Catalysis.” Eur. J. Org. Chem. 2011, 17,3238–3245, DOI: 10.1002/ejoc.201100335.

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